Tick-borne illnesses are a major source of morbidity and mortality for people inhabiting the Midwestern United States. Such diseases thus pose a significant – and, unfortunately, growing – threat to public health in the region. Prescribed burning may be able to contribute to efforts to reduce the burden posed by such illnesses by moderating the size of tick population. During this webinar, we will discuss how prescribed fire can directly and indirectly lead to such tick mortality and consider how such reductions could reduce the chance of people encountering ticks that are infected with pathogenic microorganisms. We will also explore how fire management influences other important aspects of tick-borne disease ecology, such as fire effects on wildlife hosts. Finally, we will discuss how fire management practices could be operationalized through a One Health-informed perspective in pursuit of such benefits.