Although the IRB system is not perfect, conscientious IRBs reassure the American public that the rights and welfare of human subjects are seriously considered by people who do not have a vested interest in the outcome of the research.

By exercising their responsibilities, IRBs promote the protection of human subjects. IRB approval provides a significant affirmation of the scientific and ethical quality of the research, and therefore offers important validation to the research investigator and the research institution.