In the early 1980s, revised regulations for the conduct of research with humans were published, entitled Title 45 Code of Federal Regulations Part 46, Protection of Human Subjects (45 CFR 46).

The ethical principles of The Belmont Report are embodied in these regulations; taken together The Belmont Report and 45 CFR 46 articulate the minimal ethical and legal obligations of those who conduct or support research involving human subjects.